Interesting that you mention the drive chain as that is the point that the most vibration is likely to come from yet nobody dynamically balances wheels in situ on a bike like often happens at many premium car dealerships.
Drive chain as in the method used to deliver the power to drive the vehicle. I don't mean those nasty greasy things
Take a bike that has a chain fitted. You replace the tyre and have the wheel balanced. You then fit that balanced wheel to a bike with worn sprockets and a drive chain with tight spots. When that wheel now spins is the whole assembly still balanced?
I think not