I owned an 1100S many years ago, and found it a bit of a mixed bag. Above 40 mph. it was the most comfortable bike I've ever owned, but as mentioned, round town the wrists take a lot of weight. There was a factory higher bars/screen option available, which could also be retrofitted at dealers. First gear is too tall, which also adds to the traffic pain. Also as mentioned, the drop bars, combined with the inevitable R-series weight, made it a bit of a handful to manouveure off the stand. Talkling of which, sidestand-only was standard, but centrestand available as dealer-fit option.
Handling is very nice, as with all 'R' bikes. The uprated 1100 engine is a bit coarse at lower revs, but has fairly serious kick higher up the rev range compared to the GS, and sounds very rorty even on standard cans. If you like to ride with your toes on the pegs, then the pillion footrest hangers foul your heels, but it's not a brilliant pillion bike anyway, with those grab slots instead of a rail.
The 'S' is compatible with the system luggage cases that fit the rest of the R series, and you get a full-size leftie thanks to those handsome underseat exhausts. Tank range is obviously less than a GS, but not bad for a big sports-tourer, and the cruising comfort makes it a fine distance bike. The teardrop shape also looks pretty svelte too IMO.
Don't seem to be many about these days. I thought it looked great, and I really enjoyed long rides on it, but I couldn't live with its rough edges long-term with all the town commuting I did at the time.