Bullitproof:
I'm not familiar with the Quest (I have never used one), but it operates pretty much the same way as the 2xxx series of Garmin GPSRs (2610, 2720, etc.). The screen is smaller, and I think the map storage capacity is a bit smaller also.
I think you should collect opinions from the Quest users here on the forum. They seem to be pretty happy with the unit, but they are the folks who could give you expert advice, not I.
For sure, it would be better to pay a little bit more (ca. ₤100 more) and get a Quest, rather than a SP III. However - if you can find a used 2610 that has reasonably contemporary maps (version 7 or 8 cartography) in the same price range as a new Quest - then that might be an attractive alternative, simply because you would get a bigger screen and larger map storage capacity. The bigger screen is helpful if you are over 40 years of age, and the larger map storage capacity is helpful if you plan extended trips to the continent.
If you are under 40 and plan to ride mostly in the British Isles, then a new Quest is probably a better choice than a used 2610. As you have probably discovered by now, the answers are not black and white - it's sort of a 'various shades of gray' issue. What would be the best choice for you might not be right for someone else.
Michael