My former friend, with only one functioning arm (his left) rode his ‘left hand drive’ converted bike up the Stelvio and back down again, without mishap. The only concession he asked of me, was to take his granddaughter (his regular pillion at the time) up and back down again as a pillion on my 1600.
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Him on the left, she talking to him.
His right arm from the shoulder down and his right hand are both ‘dead’ and do not work at all. The story as to how that happened and how he converted his bikes himself (tricky enough two handed, especially when you were naturally right handed) is another matter.